Meanwhile, I have been utilizing the Drosophila model to analyze the impact of patient variants on protein structure and function, and looking for their substrates which could be targeted as potential therapies. In one project, we developed two optogenetic tools, optoRaf and optoAKT, to delineate the contribution of the neurotrophic signaling pathways to neuroregeneration. To this end, I employ the Drosophila sensory neuron injury model to investigate how to promote robust neural repair and functional recovery. My research interest focuses on neurologic and neurodevelopmental disorders and how to restore the neural circuits to attenuate these diseases. I'm involved in several projects that aim to investigate the pathological function of the novel protein variants identified from neurodevelopmental patients and to explore how to promote functional axon regeneration after traumatic brain injury or neurodegeneration. Neuroscience and Neuroimaging Sino-Danish Center of Chinese Academy of Sciences, China/Aarhus University, DenmarkĢ008-2012 B.S. Cell Biology Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, ChinaĢ012-2015 M.S.
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